Nola Palestrant, Tamalpais High School
In 1928, Sir Alexander Fleming accidentally discovered humanity’s first antibiotic, Penicillin, which would come to revolutionize medicine. Antibiotics are a type of medicine that fight infections caused by bacteria. Bacteria are prokaryotes - single-celled organisms that lack a nucleus or other membrane-bound organelles. They were the first life forms to appear on earth, and have been interacting with humans since the dawn of our existence. Bacteria infect us in a variety of ways, including by penetrating our skin, riding in airborne particles that we inhale, residing in the food we eat, and transmitting through contact with vectors. Once inside our bodies, they rapidly reproduce, invading our cells to survive and grow, and sometimes releasing toxins. Though not all bacteria are harmful, those that are can infect almost every part of our bodies. Antibiotics function by killing bacteria outright or disabling their growth. Before the invention and widespread use of antibiotics, many infections were fatal, especially in vulnerable population groups. We can now cure most of them easily and are even able to prevent certain bacteria from causing harm through the use of vaccines. Antibiotics have been instrumental in allowing us to live longer and healthier lives. Here are some medical problems that were deadly in a pre-antibiotic era, but are now largely treatable with the use of antibiotics.
Strep Throat
Tuberculosis
Bacterial Meningitis
Bacterial Meningitis is a severe infection in the meninges - the three membranes that line the brain and the spinal cord. They protect the central nervous system, and in the case of meningitis, become inflamed. While meningitis can be caused by both viruses and bacteria, bacterial meningitis tends to be more harmful.
The bacterium that typically cause bacterial meningitis is streptococcus pneumoniae, neisseria meningitis, listeria monocytogenes, and staphylococcus aureus. These bacteria don’t specifically attack your meninges. As they infect other parts of your body, they cause infections there, each with its own unique complications. They result in meningitis by chance, and when they do, these bacteria can have detrimental effects.
Meningitis is frequently accompanied by sepsis, a serious condition that results in multiorgan failure and shock. Sepsis is often fatal.
Even when bacterial meningitis is not deadly, it can cause strokes and significant brain damage, leaving victims with issues such as memory problems, learning disabilities, seizures, movement disorders, and paralysis.
Even with the assistance of antibiotics, 1 in 10 people who contract bacterial meningitis will die, and 1 in 5 will experience serious complications. However, in the pre-antibiotic era, the mortality rate for bacterial meningitis was nearly 100%. Medical advances have enabled us to treat and prevent such infections through vaccination and cleanliness.
4. Childbirth
More than three million babies are born every year in the U.S., yet 1,000 mothers will die from childbirth. Five infants in every 1,000 births won’t survive. However, up until the 1930s, mothers and babies routinely perished in childbirth.
In the late 18th century, maternal death rates were estimated to be about 25 per 1,000 women. Because of the high total fertility rate (average number of children a woman bears), the likelihood of childbirth complications was significant. Sepsis, a condition where the body improperly responds to an infection, was the cause of half of these deaths. Accounting for another large portion of deaths were uterine infections that led to Puerperal fever.
British doctor Irvine Loudon described puerperal fever; “A woman could be delivered on Monday, happy and well with her newborn baby on Tuesday, feverish and ill by Wednesday evening, delirious and in agony with peritonitis on Thursday, and dead on Friday or Saturday.”
In 1900, one in every six American infants died before their first birthday. Infections were a primary contributor to this number. Death rates for mothers and infants dropped when antibiotics were developed, able to combat the bacteria responsible for so many deaths. A decreased maternal and infant mortality rate played a large role in enabling a spike in population growth. Without the development of antibiotics to lower the fatalities associated with childbirth, bringing new life into the world would be very different.
General Infections
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