Wednesday, November 13, 2019

"Star Clusters: Many-Body Gravitational Laboratories" - An Interview with Nicholas Rui of UC Berkeley

By Shoshana Harlem (MSS Intern, Terra Linda High School)

Nicholas Rui
Nicholas Rui is a current fourth-year undergraduate student at UC Berkeley who is studying physics and astrophysics.


1.  What made you interested in studying star clusters?

I was always somewhat interested in astrophysics as a child, as it seemed fantastical to me that humans would be able to gain so much intuition about the cosmos from our humble vantage point of Earth. My first research project ever, in fact, was on a dissolving star cluster near the center of the galaxy called the Quintuplet cluster, and at that time I was introduced to the fascinating dynamics that govern astrophysical objects such as these.

2. What are some interesting facts about star clusters that you have learned from studying them?

When we take our first classes in physics, one of the first things we learn is Newton's Universal Law of Gravitation, which describes a straightforward attractive force between any two objects with mass. Even though the law, at first, sounds superficial (and a bit boring), it turns out that there are some strange consequences of gravity which appear when you have millions of objects all interacting under gravity. For example, when you add energy to a normal material, you cause the atoms within it to jiggle around faster (thus raising its temperature). However, in gravitationally bound systems like star clusters, adding energy actually causes the stars in the cluster to slow down—star clusters have negative heat capacity. This causes star clusters to undergo runaway "core collapses" during which the number of stars in the cluster core rockets up, producing a dense region where stars interact very often.

3. What are the best parts of your job? What are the hardest parts of your job?

The best parts of my job are where, after a very long period of work, my code finally outputs that coveted plot outlining the answer to the question that I was asking, and being able to weave it into a coherent physical picture. The hardest parts are, of course, some of the moments in between where I am wrestling with some code bug, or when I am struggling to word a sentence in a precise enough way to communicate some physical phenomenon without going too deep into the weeds. You learn to take the good with the bad, but I promise the good is worth it.

4. What advice would you give to people who want to study star clusters?

Perhaps the most important thing for people who know they want to do astronomy is to learn how to code. When people think about what astronomers do, they often imagine rough-and-ready eccentrics pointing their backyard telescopes at Saturn, and it's true that some of us do this some of the time. However, especially in the age of big data, one of the primary jobs of the astrophysicist is making sense of the data that we obtain, and this requires being able to deal with it efficiently and with insight. Also, never give up your curiosity.

5. What current projects are you working on?

5. My most recent project has been on matching real star clusters that we actually observe to simulated star clusters based off of the brightness of the star clusters, as well as the velocities of those in the star cluster. Even though we can't see things like black holes, provided we trust our models, we can figure out how many black holes we expect to be inside a star cluster based off of things that we can measure.

Want to learn more about Nicholas Rui and star clusters? Join us on Wednesday, November 13, 2019 at Terra Linda High School from 7:30 PM - 8:30 PM in Room 207!

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Wednesday, November 6, 2019

"Let's Learn About Lysosomes" - An Interview with Gouri Yogalingam, Ph.D. of BioMarin, Novato



By Shoshana Harlem (MSS Intern, Terra Linda High School)

Dr. Gouri Yogalingam is currently working to develop therapies for treatments of genetically-defined diseases at the Bio Marin Pharmaceutical in Novato. She has already developed enzyme replacement therapy for a rare genetic disease, called mucopolysaccharidosis type Vl. 

1. What made you interested in studying lysosomes?

Dr. Gouri Yogalingam
I was working on lysosomal storage diseases in my PhD and got to know two young boys affected with MPSVI and MPS II, who came to our clinic in Adelaide, South Australia. Their names were Mathew and Vaughan. Over the years they both deteriorated and eventually died. This really affected me, making me realize how important and somewhat overlooked the lysosomal system is in terms of contributing to normal cellular homeostasis, as well as disease pathogenesis when lysosomes stop working. After my PhD I moved to the USA and into other research areas outside of lysosomal storage diseases but I think without realizing it I have always been interested in how lysosomes contribute to not only lysosomal storage diseases but also more common diseases that we all know about, like cancer and heart disease.

2. How do lysosomes contribute to cancer progression and cardiovascular disease?

In cancer cells the anti-cancer drug known as imatinib stops Abl kinase signaling and down-regulates autophagy, a lysosomal-mediated process that cancer cells have been reported to hijack to grow faster. In cardiovascular disease, a delta protein kinase C peptide inhibitor drug helps to up-regulate mitophagy, a cardio-protective lysosomal-mediated process that helps to remove damaged mitochondria in cardiomyocytes following myocardial infarction.

3. What are some benefits of lysosomes? In other words, how are they good for a person?

Think of lysosomes as the recycling center of your cells. If your lysosomes stop working old, damaged proteins and organelles build up and promote cellular damage.

4. What advice would you have to people who want to study lysosomes?

I don’t think anyone would graduate from high school wanting to specifically work on the humble old lysosome! My advice is to always think beyond the lysosome. I have several interests outside of lysosomes. For me my interest in lysosomes was because of a very emotional experience, seeing young children affected with lysosomal storage diseases passing away. The truth is that many of these kids still die and some of these diseases cannot be effectively treated with our current technologies. So perhaps the young scientists out there should take up the cause and get into this field of human disease with a fresh outlook and novel approaches that us oldies have not thought of. Assuming that high school students know that lysosomes are truly what they want to study then I guess that they should go to college and learn about cell and organelle biology. They can always reach out to me, and I'll point them in the right direction if they want to work in a lysosomal lab!

5. What has been your favorite project involving lysosomes that you have worked on?

There are many. I recently worked on a project at BioMarin, where we evaluated enzyme replacement therapy for the neurodegenerative lysosomal storage disease GM1 gangliosidosis. That was fun. We learned a lot of new things about the disease. The work that I care about the most was about a boy who was affected with another lysosomal storage disease, MPS IIIB. He passed away in his 30s after suffering from progressive neurodegeneration. I learned all about this patients genetic mutations. We worked out how the inherited mutations in this patient resulted in his unusually protracted disease symptoms. There is also the story about a naturally occurring form of MPS VI in cats, which I'll talk about at the Marin Science Seminar. Just like humans, even cats can inherit these devastating lysosomal storage disease. We learned that an extremely mild form of MPS VI can disguise itself as a very mild form of skeletal dysplasia - in cute, fluffy cats!


Crochet Seagull: Studying Sea Birds Seminar

  By Sahiti Namburu, Terra Linda High School After going to the Marine Wildlife off our Coasts: Studying Sea birds, Marine Mammals and More ...

About Us

Marin Science Seminar is a one-hour science lecture/presentation with a question and answer period open to all interested local teenagers, educators and community. Seminar sessions are held 12 Wednesday evenings during the school year, from 7:30 to 8:30 pm in the Innovation Hub at Terra Linda High School, 320 Nova Albion Way, San Rafael. Seminar speakers are scientists, mathematicians, engineers, physicians, technologists and computer programmers. The topics presented are in a specific area of the speaker’s expertise, geared to interested high school students.